Jofra Archer will miss England’s one-day series against India and the start of next month’s Indian Premier League because of his ongoing elbow problem.
The fast bowler will return home for further investigation of the issue, which the England and Wales Cricket Board (ECB) says “deteriorated” during the five-match T20 series.
Lancashire spinner Matt Parkinson is in the squad having been a T20 reserve.
World champions England face India in a three-match series, all held in Pune.
The first match starts at 08:00 GMT on Tuesday.
Archer, 25, is due to play for the Rajasthan Royals in the Indian Premier League, which runs from 9 April to 30 May.
“Jofra’s elbow issue has deteriorated over the course of the Twenty20 International series and made it increasingly challenging for him to maintain performance levels,” the ECB said in a statement.
England head coach Chris Silverwood said: “It’s obviously disappointing for Jofra and for us. He will have every resource we can give him so we can get to the bottom of what is going on.
“The important thing here is we get it cleared up, see the specialist and make sure we put everything in place for Jofra to have a long, successful international career for England in all formats.”
England Test captain Joe Root, who was not part of the T20 squad and returned home after the Test series, has been rested.
All-rounder Chris Woakes, who left the India tour before the fourth Test as part of England’s rest and rotation policy, has also been rested.
Woakes did not play a match over the winter, despite being included in squads in South Africa, Sri Lanka and India, but Silverwood said there is no issue and that “he’s having a break and spending time with his family”.
Batsman Dawid Malan and fast bowlers Jake Ball and Chris Jordan have been named as reserves.
Archer’s ongoing elbow struggles
Archer is expected to play a key role across all formats for England in 2021 – a year which includes five home Tests against India, a T20 World Cup and the Ashes in Australia.
He has regularly struggled with an elbow injury since making his international debut in 2019, missing three Tests of England’s tour of South Africa in early 2020 and the T20 series that followed.
Last month he played in the first and third Tests against India, but was ruled out of the second and fourth.
He played a full part in the subsequent T20 series, but speaking after Saturday’s defeat in the fifth T20 in Ahmedabad captain Eoin Morgan said Archer’s injury had “got worse” and “needs attention”.
In response to questions over his desire to play for England, Archer said earlier this month he will “do everything” in his power to play a full part in the T20 World Cup and Ashes.
Silverwood said it was a “joint decision” for Archer to have treatment now and “both parties have put England first”.
He added: “Jofra needs to get this right, he needs some time to do that, so we’ve made space to make sure that we give him the best chance of being successful for England.
“He wants to be at the World Cup and the Ashes, it wasn’t a difficult decision by either side. It was a sensible decision.
“It shows how passionate Jofra is about playing for England and how much he enjoys playing for England.”
England ODI Squad: Eoin Morgan, (captain), Moeen Ali, Jonathan Bairstow, Sam Billings, Jos Buttler, Sam Curran, Tom Curran, Liam Livingstone, Matt Parkinson, Adil Rashid, Jason Roy, Ben Stokes, Reece Topley, Mark Wood
Reserves: Jake Ball, Chris Jordan, Dawid Malan
India ODI squad: Virat Kohli (captain), Yuzvendra Chahal, Shikhar Dhawan, Shubman Gill, Shreyas Iyer, Prasidh Krishna, Bhuvneshwar Kumar, Thangarasu Natarajan, Hardik Pandya, Krunal Pandya, Rishabh Pant, KL Rahul, Rohit Sharma, Mohammed Siraj, Washington Sundar, Shardul Thakur, Kuldeep Yadav, Suryakumar Yadav
India ODI Tour schedule
*All matches at Pune
23 March: 1st ODI (d/n) – 08:00 GMT
26 March: 2nd ODI (d/n) – 08:00 GMT
28 March: 3rd ODI (d/n) – 09:00 BST